UFM1 antibody (AA 11-63) (Biotin)

Catalog No. ABIN7174509

Product Details anti-UFM1 Antibody (Biotin)

Target: UFM1 (Ubiquitin-Fold Modifier 1 (UFM1))

Binding Specificity: AA 11-63

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UFM1 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-fold modifier 1 protein (11-63AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UFM1

Target: UFM1 (Ubiquitin-Fold Modifier 1 (UFM1))

Alternative Name: UFM1 (UFM1 Products)

Synonyms: T32E8.4 antibody, T32E8_4 antibody, BM-002 antibody, C13orf20 antibody, bA131P10.1 antibody, 1810045K17Rik antibody, AI132708 antibody, AI463323 antibody, ENSMUSG00000074598 antibody, Gm10726 antibody, RGD1304890 antibody, UBFM1 antibody, ubfm1 antibody, wu:fa10f05 antibody, wu:fb72g01 antibody, zgc:55335 antibody, ubiquitin fold modifier 1 antibody, ubiquitin-fold modifier 1 antibody, ubiquitin-fold modifier antibody, ubiquitin-fold modifier 1 L homeolog antibody, UFM1 antibody, ufm1 antibody, CCP2 antibody, Ufm1 antibody, ufm1.L antibody, PR46a antibody

Background:

Background: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable).

Aliases: BM 002 antibody, BM002 antibody, C13orf20 antibody, Chromosome 13 open reading frame 20 antibody, Ubiquitin fold modifier 1 antibody, Ubiquitin-fold modifier 1 antibody, UFM1 antibody, UFM1_HUMAN antibody

UniProt: P61960