UBE2W antibody (AA 1-151)

Catalog No. ABIN7174502

Product Details anti-UBE2W Antibody

Target: UBE2W (Ubiquitin-Conjugating Enzyme E2W (UBE2W))

Binding Specificity: AA 1-151

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE2W antibody is un-conjugated

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-conjugating enzyme E2 W protein (1-151AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UBE2W

Target: UBE2W (Ubiquitin-Conjugating Enzyme E2W (UBE2W))

Alternative Name: UBE2W (UBE2W Products)

Synonyms: UBE2W antibody, im:6905459 antibody, si:ch211-193n21.4 antibody, ube2wa antibody, UBC-16 antibody, UBC16 antibody, 6130401J04Rik antibody, ubiquitin conjugating enzyme E2 W antibody, ubiquitin-conjugating enzyme E2W (putative) antibody, ubiquitin conjugating enzyme E2 W (putative) antibody, ubiquitin conjugating enzyme E2W (putative) antibody, ubiquitin-conjugating enzyme E2W antibody, UBE2W antibody, ube2w antibody, Ube2w antibody

Background:

Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes \'Lys-11\'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2.

Aliases: FLJ11011 antibody, hUBC 16 antibody, hUBC16 antibody, Probable ubiquitin conjugating enzyme E2 W antibody, Probable ubiquitin-conjugating enzyme E2 W antibody, UBC 16 antibody, UBC-16 antibody, UBC16 antibody, UBE 2W antibody, ube2w antibody, UBE2W_HUMAN antibody, Ubiquitin carrier protein W antibody, Ubiquitin conjugating enzyme 16 antibody, Ubiquitin conjugating enzyme E2 W antibody, Ubiquitin conjugating enzyme E2W antibody, Ubiquitin protein ligase W antibody, Ubiquitin-protein ligase W antibody

UniProt: Q96B02