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UBE2V1 antibody (AA 2-147) (Biotin)

UBE2V1 Reactivity: Human ELISA Host: Rabbit Polyclonal Biotin
Catalog No. ABIN7174490
  • Target See all UBE2V1 Antibodies
    UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))
    Binding Specificity
    • 16
    • 8
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 2-147
    Reactivity
    • 47
    • 21
    • 20
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 44
    • 3
    Rabbit
    Clonality
    • 47
    Polyclonal
    Conjugate
    • 17
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This UBE2V1 antibody is conjugated to Biotin
    Application
    • 36
    • 15
    • 14
    • 13
    • 13
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Ubiquitin-conjugating enzyme E2 variant 1 protein (2-147AA)
    Isotype
    IgG
    Top Product
    Discover our top product UBE2V1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))
    Alternative Name
    UBE2V1 (UBE2V1 Products)
    Synonyms
    CIR1 antibody, CROC-1 antibody, CROC1 antibody, UBE2V antibody, UEV-1 antibody, UEV1 antibody, UEV1A antibody, 0610011J09Rik antibody, AI256840 antibody, D7Bwg1382e antibody, CROC-1B antibody, ubiquitin conjugating enzyme E2 V1 antibody, ubiquitin-conjugating enzyme E2 variant 1 antibody, UBE2V1 antibody, ube2v1 antibody, Ube2v1 antibody
    Background

    Background: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate \'Lys-63\'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.

    Aliases: CIR1 antibody, CROC-1 antibody, CROC1 antibody, CROC1A antibody, TRAF6-regulated IKK activator 1 beta Uev1A antibody, UB2V1_HUMAN antibody, UBE2V 1 antibody, UBE2V antibody, UBE2V1 antibody, Ubiquitin conjugating enzyme E2 variant 1 antibody, Ubiquitin-conjugating enzyme E2 variant 1 antibody, UEV-1 antibody, UEV1 antibody

    UniProt
    Q13404
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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