UBE2D2 antibody (AA 1-147)

Catalog No. ABIN7174438

Product Details anti-UBE2D2 Antibody

Target: UBE2D2 (Ubiquitin-Conjugating Enzyme E2D 2 (UBE2D2))

Binding Specificity: AA 1-147

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE2D2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-conjugating enzyme E2 D2 protein (1-147AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UBE2D2

Target: UBE2D2 (Ubiquitin-Conjugating Enzyme E2D 2 (UBE2D2))

Alternative Name: UBE2D2 (UBE2D2 Products)

Synonyms: E2(17)KB2 antibody, PUBC1 antibody, UBC4 antibody, UBC4/5 antibody, UBCH5B antibody, 1500034D03Rik antibody, Ubc2e antibody, Ube2d2 antibody, ubc4 antibody, ube2d2 antibody, zgc:55886 antibody, E217kB antibody, ubiquitin conjugating enzyme E2 D2 antibody, ubiquitin-conjugating enzyme E2D 2A antibody, ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) antibody, ubiquitin-conjugating enzyme E2D 2 antibody, ubiquitin conjugating enzyme E2 D3 antibody, UBE2D2 antibody, Ube2d2a antibody, ube2d2 antibody, Ube2d2 antibody, UBE2D3 antibody

Background:

Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes \\\'Lys-48\\\'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.

Aliases: E2(17)KB2 antibody, OTTHUMP00000223475 antibody, OTTHUMP00000223476 antibody, OTTHUMP00000223477 antibody, OTTHUMP00000223478 antibody, OTTHUMP00000224375 antibody, PUBC 1 antibody, PUBC1 antibody, UB2D2_HUMAN antibody, UBC 4 antibody, UBC 4/5 antibody, UBC4 antibody, UBC4/5 antibody, UBC4/5 homolog yeast antibody, UBCH 5B antibody, UBCH5B antibody, UBE2D2 antibody, Ubiquitin carrier protein antibody, Ubiquitin carrier protein D2 antibody, Ubiquitin conjugating enzyme E2 17 kDa 2 antibody, Ubiquitin conjugating enzyme E2 D2 antibody, Ubiquitin conjugating enzyme E2D 2 (homologous to yeast UBC4/5) antibody, Ubiquitin conjugating enzyme E2D 2 (UBC4/5 homolog yeast) antibody, Ubiquitin conjugating enzyme E2D 2 antibody, Ubiquitin protein ligase D2 antibody, Ubiquitin-conjugating enzyme E2 D2 antibody, Ubiquitin-conjugating enzyme E2(17)KB 2 antibody, Ubiquitin-conjugating enzyme E2-17 kDa 2 antibody, Ubiquitin-protein ligase D2 antibody

UniProt: P62837

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades