UBASH3A antibody (AA 287-455)

Catalog No. ABIN7174413

Product Details anti-UBASH3A Antibody

Target: UBASH3A (Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A))

Binding Specificity: AA 287-455

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBASH3A antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-associated and SH3 domain-containing protein A protein (287-455AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UBASH3A

Target: UBASH3A (Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A))

Alternative Name: UBASH3A (UBASH3A Products)

Synonyms: UBASH3A antibody, CLIP4 antibody, STS-2 antibody, TULA antibody, TULA-1 antibody, 5830413C03Rik antibody, C330001M22 antibody, Sts-2 antibody, ubiquitin associated and SH3 domain containing A antibody, ubiquitin associated and SH3 domain containing, A antibody, UBASH3A antibody, Ubash3a antibody

Background:

Background: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH . May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

Aliases: Cbl interacting protein 4 antibody, Cbl-interacting protein 4 antibody, CLIP4 antibody, STS 2 antibody, STS-2 antibody, Suppressor of T cell receptor signaling 2 antibody, Suppressor of T-cell receptor signaling 2 antibody, T cell ubiquitin ligand antibody, T cell ubiquitin ligand protein antibody, T-cell ubiquitin ligand 1 antibody, TULA antibody, TULA-1 antibody, UBASH3A antibody, ubiquitin associated and SH3 domain containing, A antibody, Ubiquitin-associated and SH3 domain-containing protein A antibody, UBS3A_HUMAN antibody

UniProt: P57075