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USP8 antibody (C-Term)

USP8 Reactivity: Human WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7174360
  • Target See all USP8 Antibodies
    USP8 (Ubiquitin Specific Peptidase 8 (USP8))
    Binding Specificity
    • 8
    • 7
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-270, C-Term
    Reactivity
    • 35
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 32
    • 2
    • 1
    Rabbit
    Clonality
    • 33
    • 2
    Polyclonal
    Conjugate
    • 25
    • 2
    • 2
    • 2
    • 2
    • 2
    This USP8 antibody is un-conjugated
    Application
    • 31
    • 14
    • 12
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Cross-Reactivity
    Human
    Purification
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Ubiquitin carboxyl-terminal hydrolase 8 protein (1-270AA)
    Isotype
    IgG
    Top Product
    Discover our top product USP8 Primary Antibody
  • Application Notes
    Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    USP8 (Ubiquitin Specific Peptidase 8 (USP8))
    Alternative Name
    USP8 (USP8 Products)
    Synonyms
    HumORF8 antibody, UBPY antibody, AI574262 antibody, AW557536 antibody, Ubpy antibody, mKIAA0055 antibody, ubiquitin carboxyl-terminal hydrolase 8 antibody, ubiquitin specific peptidase 8 antibody, LOC9310109 antibody, MGYG_00369 antibody, USP8 antibody, Usp8 antibody
    Background

    Background: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both \\\'Lys-48\\\' an \\\'Lys-63\\\'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.

    Aliases: Deubiquitinating enzyme 8 antibody, FLJ34456 antibody, hUBPy antibody, HumORF8 antibody, KIAA0055 antibody, MGC129718 antibody, SPG59 antibody, Ubiquitin carboxyl-terminal hydrolase 8 antibody, Ubiquitin isopeptidase Y antibody, ubiquitin specific peptidase 8 antibody, Ubiquitin thioesterase 8 antibody, Ubiquitin-specific-processing protease 8 antibody, UBP8_HUMAN antibody, UBPY antibody, Usp8 antibody

    UniProt
    P40818
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