USP14 antibody (C-Term)

Catalog No. ABIN7174258

Product Details anti-USP14 Antibody

Target: USP14 (Ubiquitin Specific Peptidase 14 (USP14))

Binding Specificity: AA 1-494, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP14 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 14 protein (1-494AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for USP14

Target: USP14 (Ubiquitin Specific Peptidase 14 (USP14))

Alternative Name: USP14 (USP14 Products)

Background:

Background: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).

Aliases: Deubiquitinating enzyme 14 antibody, TGT antibody, tRNA guanine transglycosylase 60 kD subunit antibody, tRNA guanine transglycosylase antibody, Ubiquitin carboxyl terminal hydrolase 14 antibody, Ubiquitin carboxyl-terminal hydrolase 14 antibody, Ubiquitin specific peptidase 14 antibody, Ubiquitin specific processing protease 14 antibody, Ubiquitin specific protease 14 antibody, Ubiquitin thiolesterase 14 antibody, Ubiquitin-specific-processing protease 14 antibody, UBP14_HUMAN antibody, USP 14 antibody, USP14 antibody

UniProt: P54578