LSM6 antibody (AA 1-80)

Catalog No. ABIN7174196

Product Details anti-LSM6 Antibody

Target: LSM6 (LSM6 Homolog, U6 Small Nuclear RNA Associated (LSM6))

Binding Specificity: AA 1-80

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LSM6 antibody is un-conjugated

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human U6 snRNA-associated Sm-like protein LSm6 protein (1-80AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for LSM6

Target: LSM6 (LSM6 Homolog, U6 Small Nuclear RNA Associated (LSM6))

Alternative Name: LSM6 (LSM6 Products)

Synonyms: zgc:92379 antibody, YDR378C antibody, 1500031N17Rik antibody, 2410088K19Rik antibody, AI747288 antibody, RGD1561937 antibody, LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated S homeolog antibody, LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated antibody, lsm6.S antibody, lsm6 antibody, LSM6 antibody, Lsm6 antibody

Background:

Background: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5\'-to-3\' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3\'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).

Aliases: LSM6U6 snRNA-associated Sm-like protein LSm6 antibody

UniProt: P62312