TDP1 antibody (AA 1-260)

Catalog No. ABIN7174129

Product Details anti-TDP1 Antibody

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Binding Specificity: AA 1-260

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TDP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Cross-Reactivity: Human, Mouse, Rat

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Tyrosyl-DNA phosphodiesterase 1 protein (1-260AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:2000, IHC:1:20-1:200, IP:1:200-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TDP1

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Alternative Name: TDP1 (TDP1 Products)

Synonyms: 2810481F14Rik antibody, 4921509N21Rik antibody, AI838772 antibody, AW493413 antibody, E430034L06Rik antibody, MLZ-501 antibody, SCAN1 antibody, tdp1 antibody, MGC83708 antibody, TDP1 antibody, F8M21.60 antibody, F8M21_60 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, tyrosyl-DNA Phosphodiesterase (Tdp1) antibody, tyrosyl-DNA phosphodiesterase 1 L homeolog antibody, tyrosyl-DNA phosphodiesterase-like protein antibody, TDP1 antibody, Tc00.1047053511191.10 antibody, Tdp1 antibody, tdp1.L antibody, tdp1 antibody, PTRG_11198 antibody, MCYG_02121 antibody, MGYG_03035 antibody

Background:

Background: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3\\\'-phosphodiester bond, giving rise to DNA with a free 3\\\' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3\\\'-phosphoglycolates on protruding 3\\\' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3\\\'exonuclease activity and can remove a single nucleoside from the 3\\\'end of DNA and RNA molecules with 3\\\'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3\\\'phosphate.

Aliases: AI838772 antibody, AW493413 antibody, FLJ11090 antibody, MGC104252 antibody, MGC112732 antibody, RP24-311F12.2 antibody, SCAN1 antibody, TDP1 antibody, TYDP antibody, TYDP1_HUMAN antibody, Tyr-DNA phosphodiesterase 1 antibody, Tyrosyl-DNA phosphodiesterase 1 antibody

UniProt: Q9NUW8