BLK antibody (AA 1-280)

Catalog No. ABIN7174010

Product Details anti-BLK Antibody

Target: BLK (B Lymphoid Tyrosine Kinase (BLK))

Binding Specificity: AA 1-280

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BLK antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Tyrosine-protein kinase Blk protein (1-280AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BLK

Target: BLK (B Lymphoid Tyrosine Kinase (BLK))

Alternative Name: BLK (BLK Products)

Synonyms: bltk antibody, si:dkey-33i22.2 antibody, zgc:136231 antibody, MODY11 antibody, BLK proto-oncogene, Src family tyrosine kinase antibody, B lymphoid kinase antibody, blk antibody, BLK antibody, Blk antibody

Background:

Background: Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at \\\'Tyr-188\\\'and \\\'Tyr-199\\\', as well as CD79B at \\\'Tyr-196\\\' and \\\'Tyr-207\\\'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.

Aliases: B lymphocyte kinase antibody, B lymphoid tyrosine kinase antibody, Blk antibody, BLK nonreceptor tyrosine kinase antibody, BLK_HUMAN antibody, EC 2.7.10.2 antibody, MGC 10442 antibody, MGC10442 antibody, MODY 11 antibody, MODY11 antibody, P55 BLK antibody, p55-BLK antibody, Tyrosine kinase B lymphocyte specific antibody, Tyrosine protein kinase antibody, Tyrosine-protein kinase BLK antibody

UniProt: P51451

Pathways: Positive Regulation of Peptide Hormone Secretion, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling