TSEN2 antibody (AA 1-220)

Catalog No. ABIN7173541

Product Details anti-TSEN2 Antibody

Target: TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Binding Specificity: AA 1-220

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSEN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human tRNA-splicing endonuclease subunit Sen2 protein (1-220AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:1000, IHC:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TSEN2

Target: TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Alternative Name: TSEN2 (TSEN2 Products)

Synonyms: AU067695 antibody, RGD1309946 antibody, PCH2B antibody, SEN2 antibody, SEN2L antibody, tRNA splicing endonuclease subunit 2 antibody, TSEN2 antibody, Tsen2 antibody

Background:

Background: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5\\\'- and 3\\\'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2\\\',3\\\'-cyclic phosphate and 5\\\'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5\\\'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3\\\'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3\\\'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.

Aliases: HsSen2 antibody, MGC2776 antibody, MGC4440 antibody, SEN2 antibody, SEN2_HUMAN antibody, SEN2L antibody, tRNA intron endonuclease Sen2 antibody, tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae) antibody, tRNA splicing endonuclease subunit Sen2 antibody, tRNA-intron endonuclease sen2 antibody, tRNA-splicing endonuclease subunit Sen2 antibody, TSEN 2 antibody, TSEN2 antibody

UniProt: Q8NCE0

Pathways: Nuclear Receptor Transcription Pathway, Regulation of Lipid Metabolism by PPARalpha