TSEN15 antibody (AA 1-171) (Biotin)

Catalog No. ABIN7173537

Product Details anti-TSEN15 Antibody (Biotin)

Target: TSEN15 (tRNA Splicing Endonuclease 15 Homolog (TSEN15))

Binding Specificity: AA 1-171

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSEN15 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human tRNA-splicing endonuclease subunit Sen15 protein (1-171AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TSEN15

Target: TSEN15 (tRNA Splicing Endonuclease 15 Homolog (TSEN15))

Alternative Name: TSEN15 (TSEN15 Products)

Synonyms: 5730449L18Rik antibody, AL023077 antibody, Sen15 antibody, C1orf19 antibody, sen15 antibody, tRNA splicing endonuclease subunit 15 antibody, Tsen15 antibody, TSEN15 antibody

Background:

Background: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5\' and 3\' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2\',3\' cyclic phosphate and 5\'-OH termini (PubMed:15109492, PubMed:27392077). There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3\'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3\'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (PubMed:15109492).

Aliases: TSEN15 antibody, C1orf19 antibody, SEN15 antibody, tRNA-splicing endonuclease subunit Sen15 antibody, SEN15 homolog antibody, HsSEN15 antibody, tRNA-intron endonuclease Sen15 antibody

UniProt: Q8WW01