TGS1 antibody (AA 714-853)

Catalog No. ABIN7173394

Product Details anti-TGS1 Antibody

Target: TGS1 (Trimethylguanosine Synthase 1 (TGS1))

Binding Specificity: AA 714-853

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGS1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Trimethylguanosine synthase protein (714-853AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TGS1

Target: TGS1 (Trimethylguanosine Synthase 1 (TGS1))

Alternative Name: TGS1 (TGS1 Products)

Synonyms: NCOA6IP antibody, PIMT antibody, PIPMT antibody, D4Ertd800e antibody, Ncoa6ip antibody, Pimt antibody, trimethylguanosine synthase 1 antibody, trimethylguanosine synthase 1 L homeolog antibody, TGS1 antibody, Tgs1 antibody, tgs1.L antibody

Background:

Background: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

Aliases: Cap specific guanine N2 methyltransferase antibody, Cap-specific guanine-N2 methyltransferase antibody, CLL associated antigen KW 2 antibody, CLL-associated antigen KW-2 antibody, DKFZp762A163 antibody, FLJ22995 antibody, HCA137 antibody, Hepatocellular carcinoma associated antigen 137 antibody, Hepatocellular carcinoma-associated antigen 137 antibody, NCOA6IP antibody, Nuclear receptor coactivator 6 interacting protein antibody, Nuclear receptor coactivator 6-interacting protein antibody, PIMT antibody, PIPMT antibody, PRIP interacting protein PIPMT antibody, PRIP interacting protein with methyltransferase domain antibody, PRIP interacting protein with methyltransferase motif antibody, PRIP-interacting protein with methyltransferase motif antibody, SEREX defined antibody, TGS 1 antibody, Tgs1 antibody, TGS1_HUMAN antibody, Trimethylguanosine synthase antibody, Trimethylguanosine synthase homolog (S. cerevisiae) antibody, Trimethylguanosine synthase homolog antibody

UniProt: Q96RS0

Pathways: Mitotic G1-G1/S Phases, Regulation of Lipid Metabolism by PPARalpha, Ribonucleoprotein Complex Subunit Organization