TMEM64 antibody (AA 40-118) (HRP)

Catalog No. ABIN7173260

Product Details anti-TMEM64 Antibody (HRP)

Target: TMEM64 (Transmembrane Protein 64 (TMEM64))

Binding Specificity: AA 40-118

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM64 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Transmembrane protein 64 protein (40-118AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TMEM64

Target: TMEM64 (Transmembrane Protein 64 (TMEM64))

Alternative Name: TMEM64 (TMEM64 Products)

Synonyms: 9630015D15Rik antibody, AI790744 antibody, AV300874 antibody, transmembrane protein 64 antibody, TMEM64 antibody, Tmem64 antibody

Background:

Background: Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.

Aliases: TMEM64 antibody, TMM64_HUMAN antibody, Transmembrane protein 64 antibody

UniProt: Q6YI46