TRPM4 antibody (AA 1-240)

Catalog No. ABIN7172867

Product Details anti-TRPM4 Antibody

Target: TRPM4 (Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4))

Binding Specificity: AA 1-240

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPM4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Transient receptor potential cation channel subfamily M member 4 protein (1-240AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRPM4

Target: TRPM4 (Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4))

Alternative Name: TRPM4 (TRPM4 Products)

Synonyms: PFHB1B antibody, TRPM4B antibody, LTrpC-4 antibody, Mls2s antibody, 1110030C19Rik antibody, AW047689 antibody, LTRPC4 antibody, TRPM4 antibody, transient receptor potential cation channel subfamily M member 4 antibody, transient receptor potential cation channel, subfamily M, member 4 antibody, TRPM4 antibody, Trpm4 antibody

Background:

Background: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.

Aliases: 1110030C19Rik antibody, AW047689 antibody, Calcium-activated non-selective cation channel 1 antibody, FLJ20041 antibody, hTRPM4 antibody, Long transient receptor potential channel 4 antibody, LTrpC-4 antibody, LTrpC4 antibody, Melastatin 4 antibody, Melastatin like 2 protein antibody, Melastatin-4 antibody, Melastatin-like 2 antibody, Mls2s antibody, PFHB1B antibody, Transient receptor potential cation channel subfamily M member 4 antibody, Transient receptor potential cation channel, subfamily M, member 4 antibody, Trpm4 antibody, TRPM4_HUMAN antibody, TRPM4B antibody

UniProt: Q8TD43

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response