TGFB3 antibody (AA 301-412)

Catalog No. ABIN7172834

Product Details anti-TGFB3 Antibody

Target: TGFB3 (Transforming Growth Factor, beta 3 (TGFB3))

Binding Specificity: AA 301-412

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGFB3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Transforming growth factor beta-3 proprotein protein (301-412AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:50-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TGFB3

Target: TGFB3 (Transforming Growth Factor, beta 3 (TGFB3))

Alternative Name: TGFB3 (TGFB3 Products)

Synonyms: TGFB3 antibody, ARVD antibody, TGF-beta3 antibody, Tgfb-3 antibody, TGF-B3 antibody, TGFbeta3 antibody, wu:fc78g09 antibody, zgc:92058 antibody, transforming growth factor beta 3 antibody, transforming growth factor, beta 3 antibody, TGFB3 antibody, Tgfb3 antibody, tgfb3 antibody

Background:

Background: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.Latency-associated peptide: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with \\\'milieu molecules\\\', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3.Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with \\\'milieu molecules\\\', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).

Aliases: ARVD antibody, ARVD1 antibody, FLJ16571 antibody, LDS5 antibody, MGC105479 antibody, MGC118722 antibody, prepro-transforming growth factor beta-3 antibody, RNHF antibody, TGF beta 3 antibody, TGF beta3 antibody, TGF-beta-3 antibody, TGFB 3 antibody, Tgfb3 antibody, TGFB3_HUMAN antibody, transforming growth factor beta 3 antibody, Transforming growth factor beta-3 antibody

UniProt: P10600

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus