LRRC32 antibody (AA 301-500)

Catalog No. ABIN7172807

Product Details anti-LRRC32 Antibody

Target: LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))

Binding Specificity: AA 301-500

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRC32 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Transforming growth factor beta activator LRRC32 protein (301-500AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for LRRC32

Target: LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))

Alternative Name: LRRC32 (LRRC32 Products)

Synonyms: D11S833E antibody, GARP antibody, AI426318 antibody, D11S833Eh antibody, D7H11S833E antibody, EG434215 antibody, Garp antibody, leucine rich repeat containing 32 antibody, LRRC32 antibody, Lrrc32 antibody

Background:

Background: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity).

Aliases: D11S833E antibody, GARP antibody, Garpin antibody, Glycoprotein A repetitions predominant antibody, Leucine rich repeat containing 32 antibody, Leucine-rich repeat-containing protein 32 antibody, LRC32_HUMAN antibody, LRRC32 antibody

UniProt: Q14392

Pathways: Activated T Cell Proliferation