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CTCFL antibody (AA 1-270)

CTCFL Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7172781
  • Target See all CTCFL Antibodies
    CTCFL (CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL))
    Binding Specificity
    • 15
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-270
    Reactivity
    • 27
    • 11
    • 3
    Human
    Host
    • 30
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 31
    • 2
    Polyclonal
    Conjugate
    • 15
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CTCFL antibody is un-conjugated
    Application
    • 28
    • 13
    • 13
    • 11
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Transcriptional repressor CTCFL protein (1-270AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    CTCFL (CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL))
    Alternative Name
    CTCFL (CTCFL Products)
    Synonyms
    BORIS antibody, CT27 antibody, CTCF-T antibody, HMGB1L1 antibody, dJ579F20.2 antibody, CTCFL antibody, Boris antibody, OTTMUSG00000016680 antibody, CCCTC-binding factor like antibody, CCCTC-binding factor (zinc finger protein)-like antibody, CTCFL antibody, Ctcfl antibody
    Background

    Background: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 \\\'Arg-3\\\' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.

    Aliases: BORIS like protein antibody, Brother of the regulator of imprinted sites antibody, Cancer/testis antigen 27 antibody, CCCTC binding factor (zinc finger protein) like antibody, CCCTC-binding factor antibody, CT27 antibody, CTCF paralog antibody, CTCF T antibody, CTCF-like protein antibody, Ctcfl antibody, CTCFL_HUMAN antibody, dJ579F20.2 antibody, HMG 1L1 antibody, HMGB1L1 antibody, MGC163358 antibody, MGC169105 antibody, MGC169106 antibody, Putative high mobility group protein 1 like 1 antibody, Putative high mobility group protein B1 like 1 antibody, Transcriptional repressor CTCFL antibody, Zinc finger protein CTCF-T antibody

    UniProt
    Q8NI51
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