MAFB antibody (AA 168-323) (Biotin)

Catalog No. ABIN7172579

Product Details anti-MAFB Antibody (Biotin)

Target: MAFB (Transcription Factor MafB (MAFB))

Binding Specificity: AA 168-323

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAFB antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Transcription factor MafB protein (168-323AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MAFB

Target: MAFB (Transcription Factor MafB (MAFB))

Alternative Name: MAFB (MAFB Products)

Synonyms: MAFB antibody, krml antibody, Maf-B antibody, XMafB antibody, kreisler antibody, MGC108453 antibody, valentino antibody, KRML antibody, MCTO antibody, Krml antibody, b-maf antibody, kr antibody, mafb antibody, val antibody, wu:fc22d11 antibody, wu:fj82a09 antibody, Kreisler antibody, Krml1 antibody, MAF bZIP transcription factor B antibody, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B antibody, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B S homeolog antibody, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba antibody, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) antibody, MAFB antibody, mafb antibody, mafb.S antibody, Mafb antibody, mafba antibody

Background:

Background: Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.

Aliases: Kreisler antibody, Kreisler (mouse) maf related leucine zipper homolog antibody, Kreisler maf related leucine zipper homolog antibody, KRML antibody, MAF bZIP transcription factor B antibody, Maf-B antibody, Mafb antibody, MAFB/Kreisler basic region/leucine zipper transcription factor antibody, MAFB_HUMAN antibody, MGC43127 antibody, Segmentation protein KR antibody, Transcription factor MafB antibody, V maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) antibody, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B antibody

UniProt: Q9Y5Q3