TFEB antibody (AA 1-476)

Catalog No. ABIN7172536

Product Details anti-TFEB Antibody

Target: TFEB (Transcription Factor EB (TFEB))

Binding Specificity: AA 1-476

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFEB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Transcription factor EB protein (1-476AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TFEB

Target: TFEB (Transcription Factor EB (TFEB))

Alternative Name: TFEB (TFEB Products)

Synonyms: TFEB antibody, tcfeb antibody, MGC145796 antibody, alphatfeb antibody, ALPHATFEB antibody, BHLHE35 antibody, TCFEB antibody, Tcfeb antibody, bHLHe35 antibody, transcription factor EB antibody, TFEB antibody, tfeb antibody, Tfeb antibody

Background:

Background: Transcription factor that specifically recognizes and binds E-box sequences (5\\\'-CANNTG-3\\\'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5\\\'-GTCACGTGAC-3\\\') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

Aliases: Alpha TFEB antibody, AlphaTFEB antibody, bHLHe35 antibody, Class E basic helix-loop-helix protein 35 antibody, T cell transcription factor EB antibody, TCFEB antibody, TFEB antibody, TFEB_HUMAN antibody, Transcription factor EB antibody

UniProt: P19484