TNIK antibody (AA 523-714)
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- Target See all TNIK Antibodies
- TNIK (TRAF2 and NCK Interacting Kinase (TNIK))
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Binding Specificity
- AA 523-714
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TNIK antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human TRAF2 and NCK-interacting protein kinase protein (523-714AA)
- Isotype
- IgG
- Top Product
- Discover our top product TNIK Primary Antibody
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- Application Notes
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- TNIK (TRAF2 and NCK Interacting Kinase (TNIK))
- Alternative Name
- TNIK (TNIK Products)
- Synonyms
- RGD1561817 antibody, TNIK antibody, 1500031A17Rik antibody, 4831440I19Rik antibody, AI451411 antibody, C530008O15Rik antibody, C630040K21Rik antibody, fc52d11 antibody, msn antibody, tnikl antibody, wu:fc52d11 antibody, zgc:63535 antibody, im:6898857 antibody, zgc:123033 antibody, zgc:152783 antibody, tnik antibody, TRAF2 and NCK interacting kinase antibody, TRAF2 and NCK interacting kinase a antibody, TRAF2 and NCK interacting kinase b antibody, TRAF2 and NCK interacting kinase S homeolog antibody, TNIK antibody, Tnik antibody, tnika antibody, tnikb antibody, tnik.S antibody
- Background
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Background: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
Aliases: EC 2.7.11.1 antibody, KIAA0551 antibody, Tnik antibody, TNIK_HUMAN antibody, Traf2 and NCK interacting kinase antibody, Traf2 and NCK-interacting protein kinase antibody
- UniProt
- Q9UKE5
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