TRAF3 antibody (AA 1-40) (Biotin)

Catalog No. ABIN7172237

Product Details anti-TRAF3 Antibody (Biotin)

Target: TRAF3 (TNF Receptor-Associated Factor 3 (TRAF3))

Binding Specificity: AA 1-40

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAF3 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human TNF receptor-associated factor 3 protein (1-40AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRAF3

Target: TRAF3 (TNF Receptor-Associated Factor 3 (TRAF3))

Alternative Name: TRAF3 (TRAF3 Products)

Synonyms: CAP-1 antibody, CAP1 antibody, CD40bp antibody, CRAF1 antibody, IIAE5 antibody, LAP1 antibody, AI528849 antibody, T-BAM antibody, amn antibody, TNF receptor associated factor 3 antibody, TNF receptor-associated factor 3 antibody, Tnf receptor-associated factor 3 antibody, TRAF3 antibody, Traf3 antibody

Background:

Background: Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote \'Lys-63\'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.

Aliases: CAP 1 antibody, CAP-1 antibody, CAP1 antibody, CD40 associated protein 1 antibody, CD40 binding protein antibody, CD40 bp antibody, CD40 receptor associated factor 1 antibody, CD40 receptor-associated factor 1 antibody, CD40-binding protein antibody, CD40BP antibody, CRAF 1 antibody, CRAF1 antibody, IIAE5 antibody, LAP 1 antibody, LAP1 antibody, LMP1 associated protein antibody, LMP1-associated protein 1 antibody, MIPT3 antibody, TNF receptor associated factor 3 antibody, TNF receptor-associated factor 3 antibody, TRAF 3 antibody, Traf3 antibody, TRAF3_HUMAN antibody

UniProt: Q13114

Pathways: NF-kappaB Signaling, Apoptosis, TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades