THOC6 antibody (AA 56-315)

Catalog No. ABIN7172063

Product Details anti-THOC6 Antibody

Target: THOC6 (THO Complex 6 Homolog (THOC6))

Binding Specificity: AA 56-315

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THOC6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human THO complex subunit 6 homolog protein (56-315AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for THOC6

Target: THOC6 (THO Complex 6 Homolog (THOC6))

Alternative Name: THOC6 (THOC6 Products)

Synonyms: WDR58 antibody, fSAP35 antibody, F830014G06Rik antibody, Wdr58 antibody, Pdrp antibody, zgc:101618 antibody, thoc6 antibody, THO complex 6 antibody, THO complex 6 homolog (Drosophila) antibody, THO complex 6 L homeolog antibody, THOC6 antibody, Thoc6 antibody, thoc6 antibody, thoc6.L antibody

Background:

Background: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5\' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi\'s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.

Aliases: THOC6 antibody, WDR58 antibody, PSEC0006 antibody, THO complex subunit 6 homolog antibody, Functional spliceosome-associated protein 35 antibody, fSAP35 antibody, WD repeat-containing protein 58 antibody

UniProt: Q86W42