THO Complex 5 antibody (AA 2-53)

Catalog No. ABIN7172059

Product Details anti-THO Complex 5 Antibody

Target: THO Complex 5 (THOC5)

Binding Specificity: AA 2-53

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THO Complex 5 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human THO complex subunit 5 homolog protein (2-53AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for THO Complex 5

Target: THO Complex 5 (THOC5)

Alternative Name: THOC5 (THOC5 Products)

Synonyms: C22orf19 antibody, Fmip antibody, PK1.3 antibody, fSAP79 antibody, 1700060C24Rik antibody, A430085L24Rik antibody, Sgk2 antibody, fc54b09 antibody, wu:fc54b09 antibody, zgc:56190 antibody, zgc:76912 antibody, THOC5 antibody, fmip antibody, thoc5 antibody, thoc5-a antibody, thoc5-b antibody, THO complex 5 antibody, THO complex 5 S homeolog antibody, THO complex 5 L homeolog antibody, THOC5 antibody, Thoc5 antibody, thoc5 antibody, thoc5.S antibody, thoc5.L antibody

Background:

Background: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5\\\' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi\\\'s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5\\\' region of target genes, probably mediates association of the TREX and CFIm complexes.

Aliases: C22orf19 antibody, Chromosome 22 open reading frame 19 antibody, Fmip antibody, Fms interacting protein antibody, fSAP79 antibody, Functional spliceosome-associated protein 79 antibody, hTREX90 antibody, KIAA0983 antibody, LOC400922 antibody, NF2/meningioma region protein pK1.3 antibody, PK1.3 antibody, Placental protein 39.2 antibody, PP39.2 antibody, THO complex 5 antibody, THO complex subunit 5 antibody, THO complex subunit 5 homolog antibody, thoc5 antibody, THOC5_HUMAN antibody

UniProt: Q13769