THO Complex 3 antibody (AA 2-351)

Catalog No. ABIN7172051

Product Details anti-THO Complex 3 Antibody

Target: THO Complex 3 (THOC3)

Binding Specificity: AA 2-351

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THO Complex 3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human THO complex subunit 3 protein (2-351AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for THO Complex 3

Target: THO Complex 3 (THOC3)

Alternative Name: THOC3 (THOC3 Products)

Synonyms: THOC3 antibody, zgc:100815 antibody, THO3 antibody, hTREX45 antibody, 2410044K02Rik antibody, AL033344 antibody, THO complex 3 antibody, THO complex subunit 3 antibody, THOC3 antibody, thoc3 antibody, LOC100400596 antibody, Thoc3 antibody

Background:

Background: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5\' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi\'s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Aliases: hTREX45 antibody, TEX1 homolog antibody, THO complex subunit 3 antibody, Tho3 antibody, THOC3 antibody, THOC3_HUMAN antibody

UniProt: Q96J01