THOC1 antibody (AA 428-657)

Catalog No. ABIN7172050

Product Details anti-THOC1 Antibody

Target: THOC1 (THO Complex 1 (THOC1))

Binding Specificity: AA 428-657

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THOC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human THO complex subunit 1 protein (428-657AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for THOC1

Target: THOC1 (THO Complex 1 (THOC1))

Alternative Name: THOC1 (THOC1 Products)

Synonyms: p84 antibody, MGC114861 antibody, Tho1 antibody, THOC1 antibody, Hpr1 antibody, HPR1 antibody, P84 antibody, P84N5 antibody, 3110002N20Rik antibody, AW107452 antibody, NMP-84 antibody, LRRGT00070 antibody, THO complex 1 antibody, THO complex 1 protein L homeolog antibody, THO complex subunit 1 antibody, THO complex 1 protein antibody, thoc1 antibody, thoc1.L antibody, THOC1 antibody, LOC100123388 antibody, Thoc1 antibody

Background:

Background: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5\\\' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi\\\'s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.

Aliases: hTREX84 antibody, Death domain containing protein p84N5 antibody, HPR 1 antibody, HPR1 antibody, hTREX84 antibody, Nuclear matrix protein p84 antibody, P84 antibody, p84N5 antibody, Tho 1 antibody, THO complex 1 antibody, THO complex subunit 1 antibody, Tho1 antibody, THOC 1 antibody, Thoc1 antibody, THOC1_HUMAN antibody

UniProt: Q96FV9