TPMT antibody (AA 4-244)

Catalog No. ABIN7171992

Product Details anti-TPMT Antibody

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Binding Specificity: AA 4-244

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPMT antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Thiopurine S-methyltransferase protein (4-244AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TPMT

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Alternative Name: TPMT (TPMT Products)

Background:

Background: TPMT is an enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.

Aliases: HGNC:12014 antibody, S adenosyl L methionine thiopurine S methyltransferase antibody, Thiopurine methyltransferase antibody, Thiopurine S methyltransferase antibody, Thiopurine S-methyltransferase antibody, TPMT antibody, TPMT_HUMAN antibody

UniProt: P51580