SOCS4 antibody (AA 1-270)

Catalog No. ABIN7171004

Product Details anti-SOCS4 Antibody

Target: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Binding Specificity: AA 1-270

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Suppressor of cytokine signaling 4 protein (1-270AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SOCS4

Target: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Alternative Name: SOCS4 (SOCS4 Products)

Background:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.

Aliases: CIS4 antibody, Cish4 antibody, Cytokine inducible SH2 protein 4 antibody, DKFZp686J1568 antibody, HSPC060 antibody, SH2 domain containing SOCS box protein antibody, SOCS-4 antibody, SOCS-7 antibody, SOCS4 antibody, SOCS4_HUMAN antibody, SOCS6 antibody, SOCS7 antibody, SSI4 antibody, STAI4 antibody, STAT induced STAT inhibitor 4 antibody, STAT4 antibody, STATI4 antibody, Suppressor of cytokine signaling 4 antibody, Suppressor of cytokine signaling 7 antibody

UniProt: Q8WXH5

Pathways: JAK-STAT Signaling, EGFR Signaling Pathway