SOCS3 antibody (AA 1-224)

Catalog No. ABIN7171000

Product Details anti-SOCS3 Antibody

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Binding Specificity: AA 1-224

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Suppressor of cytokine signaling 3 protein (1-224AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SOCS3

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Alternative Name: SOCS3 (SOCS3 Products)

Synonyms: socs3 antibody, fj09e12 antibody, zgc:56537 antibody, wu:fj09e12 antibody, MGC64393 antibody, MGC75749 antibody, xsocs3 antibody, MGC81248 antibody, atod4 antibody, cis3 antibody, cish3 antibody, socs-3 antibody, ssi-3 antibody, ssi3 antibody, SOCS3 antibody, ATOD4 antibody, CIS3 antibody, Cish3 antibody, SOCS-3 antibody, SSI-3 antibody, SSI3 antibody, Cis3 antibody, EF-10 antibody, Ef10 antibody, Ssi3 antibody, Socs-3 antibody, Ssi-3 antibody, suppressor of cytokine signaling 3a antibody, suppressor of cytokine signaling 3 S homeolog antibody, suppressor of cytokine signaling 3 antibody, suppressor of cytokine signaling 3 L homeolog antibody, socs3a antibody, socs3.S antibody, socs3 antibody, socs3.L antibody, SOCS3 antibody, Socs3 antibody

Background:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.

Aliases: ATOD4 antibody, CIS 3 antibody, CIS-3 antibody, CIS3 antibody, Cish3 antibody, Cytokine induced SH2 protein 3 antibody, Cytokine-inducible SH2 protein 3 antibody, E2a Pbx1 target gene in fibroblasts 10 antibody, EF 10 antibody, MGC71791 antibody, SOCS 3 antibody, SOCS-3 antibody, Socs3 antibody, SOCS3_HUMAN antibody, SSI 3 antibody, SSI-3 antibody, SSI3 antibody, STAT induced STAT inhibitor 3 antibody, STAT-induced STAT inhibitor 3 antibody, Suppressor of cytokine signaling 3 antibody

UniProt: O14543

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C