SOCS2 antibody (AA 1-198)

Catalog No. ABIN7170995

Product Details anti-SOCS2 Antibody

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Binding Specificity: AA 1-198

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Suppressor of cytokine signaling 2 protein (1-198AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SOCS2

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Alternative Name: SOCS2 (SOCS2 Products)

Synonyms: CIS2 antibody, Cish2 antibody, SOCS-2 antibody, SSI-2 antibody, SSI2 antibody, STATI2 antibody, Cish1 antibody, Socs-1 antibody, Socs-2 antibody, si:dkey-202b22.1 antibody, socs2 antibody, cis2 antibody, ssi2 antibody, cish2 antibody, ssi-2 antibody, socs-2 antibody, stati2 antibody, 8030460M17 antibody, AI527257 antibody, AW108012 antibody, D130043N08Rik antibody, JAB antibody, hg antibody, Cradd antibody, Socs2 antibody, suppressor of cytokine signaling 2 antibody, suppressor of cytokine signaling 1 antibody, death domain-containing protein CRADD antibody, suppressor of cytokine signaling 2 S homeolog antibody, SOCS2 antibody, Socs1 antibody, Socs2 antibody, socs2 antibody, LOC100716104 antibody, socs2.S antibody

Background:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Aliases: CIS 2 antibody, CIS-2 antibody, CIS2 antibody, Cish 2 antibody, Cish2 antibody, Cytokine inducible SH2 protein 2 antibody, Cytokine-inducible SH2 protein 2 antibody, SOCS 2 antibody, SOCS-2 antibody, Socs2 antibody, SOCS2_HUMAN antibody, SSI 2 antibody, SSI-2 antibody, SSI2 antibody, STAT induced STAT inhibitor 2 antibody, STAT-induced STAT inhibitor 2 antibody, STATI 2 antibody, STATI2 antibody, Suppressor of cytokine signaling 2 antibody

UniProt: O14508

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus