SMC6 antibody (AA 309-450) (HRP)

Catalog No. ABIN7170877

Product Details anti-SMC6 Antibody (HRP)

Target: SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))

Binding Specificity: AA 309-450

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC6 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Structural maintenance of chromosomes protein 6 protein (309-450AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SMC6

Target: SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))

Alternative Name: SMC6 (SMC6 Products)

Synonyms: SMC6L1 antibody, SMC-6 antibody, hSMC6 antibody, 2810489L22Rik antibody, 3830418C19Rik antibody, AA990493 antibody, AU018782 antibody, AW742439 antibody, Smc6l1 antibody, mKIAA4103 antibody, structural maintenance of chromosomes 6 antibody, SMC6 antibody, smc6 antibody, Smc6 antibody

Background:

Background: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).

Aliases: FLJ22116 antibody, FLJ35534 antibody, hSMC6 antibody, SMC 6 antibody, SMC protein 6 antibody, SMC-6 antibody, SMC6 antibody, SMC6 protein antibody, SMC6 structural maintenance of chromosomes 6 like 1 antibody, SMC6_HUMAN antibody, Smc6l1 antibody, Structural maintenance of chromosomes 6 antibody, Structural maintenance of chromosomes 6 like 1 antibody, Structural maintenance of chromosomes protein 6 antibody

UniProt: Q96SB8