SMC5 antibody (AA 296-403)
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- Target See all SMC5 Antibodies
- SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))
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Binding Specificity
- AA 296-403
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SMC5 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Structural maintenance of chromosomes protein 5 protein (296-403AA)
- Isotype
- IgG
- Top Product
- Discover our top product SMC5 Primary Antibody
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- Application Notes
- Recommended dilution: WB:1:500-1:5000,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))
- Alternative Name
- SMC5 (SMC5 Products)
- Synonyms
- F1N13.60 antibody, F1N13_60 antibody, structural maintenance of chromosomes 5 antibody, SMC-5 antibody, SMC5L1 antibody, MLZ-453 antibody, Smc5l1 antibody, mKIAA0594 antibody, mSMC5 antibody, structural maintenance of chromosomes 5 antibody, structural maintenance of chromosomes 5 S homeolog antibody, SMC5 antibody, smc5 antibody, Smc5 antibody, smc5.S antibody
- Background
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Background: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).
Aliases: SMC5 antibody, KIAA0594 antibody, SMC5L1 antibody, Structural maintenance of chromosomes protein 5 antibody, SMC protein 5 antibody, SMC-5 antibody, hSMC5 antibody
- UniProt
- Q8IY18
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