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SMC5 antibody (AA 296-403)

SMC5 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7170870
  • Target See all SMC5 Antibodies
    SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))
    Binding Specificity
    • 15
    • 4
    • 3
    • 1
    • 1
    • 1
    AA 296-403
    Reactivity
    • 34
    • 18
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 32
    • 1
    • 1
    Rabbit
    Clonality
    • 34
    Polyclonal
    Conjugate
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SMC5 antibody is un-conjugated
    Application
    • 22
    • 13
    • 13
    • 10
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Structural maintenance of chromosomes protein 5 protein (296-403AA)
    Isotype
    IgG
    Top Product
    Discover our top product SMC5 Primary Antibody
  • Application Notes
    Recommended dilution: WB:1:500-1:5000,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))
    Alternative Name
    SMC5 (SMC5 Products)
    Synonyms
    F1N13.60 antibody, F1N13_60 antibody, structural maintenance of chromosomes 5 antibody, SMC-5 antibody, SMC5L1 antibody, MLZ-453 antibody, Smc5l1 antibody, mKIAA0594 antibody, mSMC5 antibody, structural maintenance of chromosomes 5 antibody, structural maintenance of chromosomes 5 S homeolog antibody, SMC5 antibody, smc5 antibody, Smc5 antibody, smc5.S antibody
    Background

    Background: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).

    Aliases: SMC5 antibody, KIAA0594 antibody, SMC5L1 antibody, Structural maintenance of chromosomes protein 5 antibody, SMC protein 5 antibody, SMC-5 antibody, hSMC5 antibody

    UniProt
    Q8IY18
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