SMC1A antibody (AA 1-130)

Catalog No. ABIN7170857

Product Details anti-SMC1A Antibody

Target: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Binding Specificity: AA 1-130

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC1A antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Structural maintenance of chromosomes protein 1A protein (1-130AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SMC1A

Target: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Alternative Name: SMC1A (SMC1A Products)

Synonyms: CDLS2 antibody, DXS423E antibody, SB1.8 antibody, SMC1 antibody, SMC1L1 antibody, SMC1alpha antibody, SMCB antibody, SMC-1A antibody, NV15570 antibody, 5830426I24Rik antibody, Sb1.8 antibody, Smc1 antibody, Smc1alpha antibody, Smc1l1 antibody, Smcb antibody, mKIAA0178 antibody, smc1 antibody, smc1a antibody, smc1l1 antibody, xSMC1 antibody, smc1aa antibody, structural maintenance of chromosomes 1A antibody, structural maintenance of chromosomes 1A b antibody, structural maintenance of chromosomes 1A L homeolog antibody, SMC1A antibody, smc1a antibody, Smc1a antibody, smc1ab antibody, smc1a.L antibody

Background:

Background: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Aliases: Chromosome segregation protein SmcB antibody, DXS423E antibody, KIAA0178 antibody, MGC138332 antibody, Sb1.8 antibody, Segregation of mitotic chromosomes 1 antibody, SMC protein 1A antibody, SMC-1-alpha antibody, SMC-1A antibody, SMC1 (structural maintenance of chromosomes 1 yeast) like 1 antibody, SMC1 antibody, SMC1 structural maintenance of chromosomes 1 like 1 antibody, SMC1A antibody, SMC1A_HUMAN antibody, SMC1alpha antibody, SMC1L1 antibody, SMCB antibody, Structural maintenance of chromosomes 1A antibody, Structural maintenance of chromosomes protein 1A antibody

UniProt: Q14683

Pathways: Stem Cell Maintenance