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ESRRB antibody (AA 432-502)

ESRRB Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7170762
  • Target See all ESRRB Antibodies
    ESRRB (Estrogen-Related Receptor beta (ESRRB))
    Binding Specificity
    • 15
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 432-502
    Reactivity
    • 33
    • 23
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    Human
    Host
    • 46
    • 3
    Rabbit
    Clonality
    • 46
    • 3
    Polyclonal
    Conjugate
    • 25
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ESRRB antibody is un-conjugated
    Application
    • 34
    • 13
    • 13
    • 12
    • 11
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Steroid hormone receptor ERR2 protein (432-502AA)
    Isotype
    IgG
    Top Product
    Discover our top product ESRRB Primary Antibody
  • Application Notes
    Recommended dilution: WB:1:500-1:5000,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    ESRRB (Estrogen-Related Receptor beta (ESRRB))
    Alternative Name
    ESRRB (ESRRB Products)
    Synonyms
    errb antibody, errbeta antibody, ESRRB antibody, Err2 antibody, Errb antibody, Estrrb antibody, Nr3b2 antibody, DFNB35 antibody, ERR2 antibody, ERRb antibody, ESRL2 antibody, NR3B2 antibody, estrogen-related receptor beta antibody, estrogen related receptor beta antibody, estrogen related receptor, beta antibody, esrrb antibody, ESRRB antibody, Esrrb antibody
    Background

    Background: Isoform 3: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5\\\'TCAAGGTCA-3\\\' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186, PubMed:19755138). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:23836911). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (PubMed:17920186, PubMed:19755138). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity).

    Aliases: Err 2 antibody, ERR b antibody, ERR B2 antibody, ERR beta 2 antibody, ERR beta antibody, ERR beta-2 antibody, ERR-beta antibody, Err2 antibody, ERR2_HUMAN antibody, ERRB 2 antibody, ERRb antibody, ERRB2 antibody, ERRbeta 2 antibody, ERRbeta antibody, ESR L2 antibody, ESRL 2 antibody, ESRL2 antibody, Esrrb antibody, Estrogen receptor like 2 antibody, Estrogen receptor related 2 antibody, Estrogen receptor-like 2 antibody, Estrogen-related receptor beta antibody, Estrrb antibody, Nr3b2 antibody, Nuclear receptor ERRB2 antibody, Nuclear receptor subfamily 3 group B member 2 antibody, Orphan nuclear receptor antibody, Steroid hormone receptor ERR 2 antibody, Steroid hormone receptor ERR2 antibody

    UniProt
    O95718
    Pathways
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance
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