Spartan antibody (AA 1-239)

Catalog No. ABIN7170650

Product Details anti-Spartan Antibody

Target: Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))

Binding Specificity: AA 1-239

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Spartan antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human SprT-like domain-containing protein Spartan protein (1-239AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Spartan

Target: Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))

Alternative Name: SPRTN (C1orf124 Products)

Synonyms: Spartan antibody, c1orf124 antibody, C1orf124 antibody, DDDL1880 antibody, DVC1 antibody, PRO4323 antibody, dJ876B10.3 antibody, C28H1orf124 antibody, SprT-like N-terminal domain antibody, sprtn antibody, SPRTN antibody

Background:

Background: Regulator of UV-induced DNA damage response: acts as a \'reader\' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.

Aliases: SPRTN antibody, C1orf124 antibody, DVC1 antibody, UNQ1880/PRO4323 antibody, SprT-like domain-containing protein Spartan antibody, DNA damage protein targeting VCP antibody, DVC1 antibody, Protein with SprT-like domain at the N terminus antibody, Spartan antibody

UniProt: Q9H040