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SKA1 antibody (AA 61-134)

SKA1 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7170587
  • Target See all SKA1 Antibodies
    SKA1 (Spindle and Kinetochore Associated Complex Subunit 1 (SKA1))
    Binding Specificity
    • 15
    • 4
    • 3
    • 1
    • 1
    • 1
    AA 61-134
    Reactivity
    • 25
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 25
    Rabbit
    Clonality
    • 25
    Polyclonal
    Conjugate
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SKA1 antibody is un-conjugated
    Application
    • 20
    • 13
    • 13
    • 8
    • 5
    • 3
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Spindle and kinetochore-associated protein 1 protein (61-134AA)
    Isotype
    IgG
    Top Product
    Discover our top product SKA1 Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:200-1:500,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    SKA1 (Spindle and Kinetochore Associated Complex Subunit 1 (SKA1))
    Alternative Name
    SKA1 (SKA1 Products)
    Synonyms
    C18H18orf24 antibody, C18orf24 antibody, 2810433K01Rik antibody, AV117428 antibody, RGD1310784 antibody, spindle and kinetochore associated complex subunit 1 antibody, SKA1 antibody, ska1 antibody, Ska1 antibody
    Background

    Background: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:19289083, PubMed:23085020).

    Aliases: 2810433K01Rik antibody, AV117428 antibody, C18orf24 antibody, MGC10200 antibody, Ska1 antibody, SKA1_HUMAN antibody, Spindle and kinetochore associated complex subunit 1 antibody, Spindle and kinetochore associated protein 1 antibody, Spindle and kinetochore-associated protein 1 antibody, Spindle and KT (kinetochore) associated 1 antibody, Spindle and KT associated 1 antibody

    UniProt
    Q96BD8
    Pathways
    M Phase
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