SAMD8 antibody (AA 1-152)

Catalog No. ABIN7170561

Product Details anti-SAMD8 Antibody

Target: SAMD8 (Sterile alpha Motif Domain Containing 8 (SAMD8))

Binding Specificity: AA 1-152

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAMD8 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Sphingomyelin synthase-related protein 1 protein (1-152AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SAMD8

Target: SAMD8 (Sterile alpha Motif Domain Containing 8 (SAMD8))

Alternative Name: SAMD8 (SAMD8 Products)

Synonyms: CG32380 antibody, CG8572 antibody, CG8576 antibody, Css3beta antibody, Dmel\\CG32380 antibody, dSMSr antibody, dmSMSr antibody, SMSr antibody, 1110053F04Rik antibody, 1700010P07Rik antibody, CG32380 gene product from transcript CG32380-RA antibody, sterile alpha motif domain containing 8 antibody, SMSr antibody, SAMD8 antibody, samd8 antibody, Samd8 antibody

Background:

Background: Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.

Aliases: SAMD8Sphingomyelin synthase-related protein 1 antibody, SMSr antibody, EC 2.7.8.- antibody, Ceramide phosphoethanolamine synthase antibody, CPE synthase antibody, Sterile alpha motif domain-containing protein 8 antibody, SAM domain-containing protein 8 antibody

UniProt: Q96LT4