SPAG5 antibody (AA 1-300)

Catalog No. ABIN7170478

Product Details anti-SPAG5 Antibody

Target: SPAG5 (Sperm Associated Antigen 5 (SPAG5))

Binding Specificity: AA 1-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPAG5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Sperm-associated antigen 5 protein (1-300AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SPAG5

Target: SPAG5 (Sperm Associated Antigen 5 (SPAG5))

Alternative Name: SPAG5 (SPAG5 Products)

Synonyms: SPAG5 antibody, DEEPEST antibody, MAP126 antibody, hMAP126 antibody, AI874642 antibody, D11Bhm180e antibody, Deepest antibody, Mastrin antibody, S17 antibody, sperm associated antigen 5 antibody, sperm-associated antigen 5 antibody, SPAG5 antibody, LOC739263 antibody, Spag5 antibody

Background:

Background: Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU.

Aliases: Astrin antibody, Deepest antibody, hMAP 126 antibody, hMAP126 antibody, MAP 126 antibody, MAP126 antibody, Mitotic spindle associated protein antibody, Mitotic spindle associated protein p126 antibody, Mitotic spindle coiled coil related protein antibody, Mitotic spindle-associated protein p126 antibody, SPAG 5 antibody, SPAG5 antibody, SPAG5_HUMAN antibody, Sperm associated antigen 5 antibody, Sperm tail protein Spag 5 antibody, Sperm tail protein Spag5 antibody, Sperm-associated antigen 5 antibody

UniProt: Q96R06

Pathways: M Phase