SNX27 antibody (AA 458-497) (HRP)

Catalog No. ABIN7170384

Product Details anti-SNX27 Antibody (HRP)

Target: SNX27 (Sorting Nexin 27 (SNX27))

Binding Specificity: AA 458-497

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNX27 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Sorting nexin-27 protein (458-497AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SNX27

Target: SNX27 (Sorting Nexin 27 (SNX27))

Alternative Name: SNX27 (SNX27 Products)

Synonyms: MRT1 antibody, MY014 antibody, 5730552M22Rik antibody, ESTM45 antibody, ESTM47 antibody, R75405 antibody, mKIAA0488 antibody, Mrt1 antibody, sorting nexin family member 27 antibody, SNX27 antibody, Snx27 antibody

Background:

Background: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.

Aliases: KIAA0488 antibody, Methamphetamine responsive transcript 1 antibody, MGC126871 antibody, MGC126873 antibody, MGC20471 antibody, MRT1 antibody, MY014 antibody, OTTHUMP00000042487 antibody, RP11-98D18.12 antibody, SNX27 antibody, SNX27_HUMAN antibody, Sorting nexin family member 27 antibody, Sorting nexin-27 antibody

UniProt: Q96L92