SNX17 antibody (AA 280-457)

Catalog No. ABIN7170364

Product Details anti-SNX17 Antibody

Target: SNX17 (Sorting Nexin 17 (SNX17))

Binding Specificity: AA 280-457

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNX17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Sorting nexin-17 protein (280-457AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SNX17

Target: SNX17 (Sorting Nexin 17 (SNX17))

Alternative Name: SNX17 (SNX17 Products)

Synonyms: snx17 antibody, MGC53167 antibody, MGC69341 antibody, MGC198061 antibody, MGC83142 antibody, SNX17 antibody, wu:fb67g03 antibody, wu:fb67g09 antibody, wu:fc27g08 antibody, wu:fj81d04 antibody, si:ch211-101l18.2 antibody, 5830447M19Rik antibody, AI790646 antibody, D5Ertd260e antibody, mKIAA0064 antibody, sorting nexin 17 antibody, sorting nexin 17 L homeolog antibody, snx17 antibody, SNX17 antibody, snx17.L antibody, Snx17 antibody

Background:

Background: Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).

Aliases: Similar to a putative C elegans gene encoded in cosmid F17H10 antibody, Snx17 antibody, SNX17_HUMAN antibody, Sorting nexin 17 antibody, Sorting nexin-17 antibody

UniProt: Q15036