SLC38A9 antibody (AA 1-119)

Catalog No. ABIN7169972

Product Details anti-SLC38A9 Antibody

Target: SLC38A9 (Solute Carrier Family 38, Member 9 (SLC38A9))

Binding Specificity: AA 1-119

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC38A9 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Sodium-coupled neutral amino acid transporter 9 protein (1-119AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SLC38A9

Target: SLC38A9 (Solute Carrier Family 38, Member 9 (SLC38A9))

Alternative Name: SLC38A9 (SLC38A9 Products)

Synonyms: MGC81406 antibody, 4833412L08Rik antibody, 6720411P22Rik antibody, 9130023D20Rik antibody, 9430067K09Rik antibody, A730092C09 antibody, RGD1311881 antibody, solute carrier family 38 member 9 antibody, solute carrier family 38 member 9 L homeolog antibody, solute carrier family 38, member 9 antibody, SLC38A9 antibody, slc38a9.L antibody, slc38a9 antibody, Slc38a9 antibody

Background:

Background: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acids. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:25561175, PubMed:25567906). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids, suggesting that it acts as an amino acid sensor instead (PubMed:25561175, PubMed:25567906). The high concentration of arginine in lysosomes suggests that it acts as an arginine sensor (PubMed:25567906).

Aliases: FLJ46104 antibody, FLJ90709 antibody, Homo sapiens solute carrier family 38, member 9 antibody, MGC120544 antibody, OTTHUMP00000161835 antibody, Putative sodium coupled neutral amino acid transporter 9 antibody, Putative sodium-coupled neutral amino acid transporter 9 antibody, Putative uncharacterized protein FLJ90709 antibody, S38A9_HUMAN antibody, SLC38A9 antibody

UniProt: Q8NBW4