SIGIRR antibody (AA 1-120)
-
- Target See all SIGIRR Antibodies
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
-
Binding Specificity
- AA 1-120
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This SIGIRR antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Cross-Reactivity
- Human, Mouse
- Purification
- Antigen Affinity Purified
- Immunogen
- Recombinant Human Single Ig IL-1-related receptor protein (1-120AA)
- Isotype
- IgG
- Top Product
- Discover our top product SIGIRR Primary Antibody
-
-
- Application Notes
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Target
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
- Alternative Name
- SIGIRR (SIGIRR Products)
- Synonyms
- TIR8 antibody, AI256711 antibody, sc:d148 antibody, RGD1306732 antibody, single Ig and TIR domain containing antibody, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain antibody, SIGIRR antibody, Sigirr antibody, sigirr antibody
- Background
-
Background: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Aliases: Ig IL1 related receptor antibody, MGC110992 antibody, SIGIR_HUMAN antibody, SIGIRR antibody, Single Ig IL 1 related receptor antibody, Single Ig IL-1-related receptor antibody, Single Ig IL-1R-related molecule antibody, Single Ig IL1R Related Molecule antibody, Single immunoglobulin and toll interleukin 1 receptor (TIR) domain antibody, Single immunoglobulin and toll interleukin 1 receptor domain antibody, Single immunoglobulin domain containing IL1R related protein antibody, Single immunoglobulin domain IL1R1 related antibody, Single immunoglobulin domain-containing IL1R-related protein antibody, TIR 8 antibody, TIR8 antibody, Toll/interleukin 1 receptor 8 antibody, Toll/interleukin-1 receptor 8 antibody
- UniProt
- Q6IA17
- Pathways
- Toll-Like Receptors Cascades
-