SPPL3 antibody (AA 213-263) (HRP)

Catalog No. ABIN7169634

Product Details anti-SPPL3 Antibody (HRP)

Target: SPPL3 (Signal Peptide Peptidase 3 (SPPL3))

Binding Specificity: AA 213-263

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPPL3 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Signal peptide peptidase-like 3 protein (213-263AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SPPL3

Target: SPPL3 (Signal Peptide Peptidase 3 (SPPL3))

Alternative Name: SPPL3 (SPPL3 Products)

Background:

Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).

Aliases: SPPL3 antibody, IMP2 antibody, PSL4 antibody, Signal peptide peptidase-like 3 antibody, SPP-like 3 antibody, EC 3.4.23.- antibody, Intramembrane protease 2 antibody, IMP-2 antibody, Presenilin homologous protein 1 antibody, PSH1 antibody, Presenilin-like protein 4 antibody

UniProt: Q8TCT6