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SPPL2A antibody (AA 26-172) (HRP)

SPPL2A Reactivity: Human ELISA Host: Rabbit Polyclonal HRP
Catalog No. ABIN7169626
  • Target See all SPPL2A Antibodies
    SPPL2A (Signal Peptide Peptidase-Like 2A (SPPL2A))
    Binding Specificity
    • 7
    • 4
    • 2
    • 2
    • 1
    AA 26-172
    Reactivity
    • 16
    • 1
    • 1
    Human
    Host
    • 14
    • 2
    Rabbit
    Clonality
    • 15
    • 1
    Polyclonal
    Conjugate
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    This SPPL2A antibody is conjugated to HRP
    Application
    • 13
    • 13
    • 10
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Signal peptide peptidase-like 2A protein (26-172AA)
    Isotype
    IgG
    Top Product
    Discover our top product SPPL2A Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    SPPL2A (Signal Peptide Peptidase-Like 2A (SPPL2A))
    Alternative Name
    SPPL2A (SPPL2A Products)
    Synonyms
    RGD1563001 antibody, SPPL2A antibody, LOC453430 antibody, LOC100231183 antibody, IMP3 antibody, PSL2 antibody, 2010106G01Rik antibody, C130089K23Rik antibody, signal peptide peptidase-like 2A antibody, signal peptide peptidase like 2A antibody, Signal peptide peptidase-like 2A antibody, Sppl2a antibody, SPPL2A antibody, sppl2a antibody, psl2 antibody
    Background

    Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).

    Aliases: SPPL2A antibody, IMP3 antibody, PSL2 antibody, PSEC0147 antibody, Signal peptide peptidase-like 2A antibody, SPP-like 2A antibody, SPPL2a antibody, EC 3.4.23.- antibody, Intramembrane protease 3 antibody, IMP-3 antibody, Presenilin-like protein 2 antibody

    UniProt
    Q8TCT8
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