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WNK4 antibody (AA 828-1106) (FITC)

WNK4 Reactivity: Human Host: Rabbit Polyclonal FITC
Catalog No. ABIN7169236
  • Target See all WNK4 Antibodies
    WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))
    Binding Specificity
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 828-1106
    Reactivity
    • 47
    • 32
    • 27
    • 4
    • 1
    Human
    Host
    • 48
    • 2
    Rabbit
    Clonality
    • 48
    • 2
    Polyclonal
    Conjugate
    • 13
    • 5
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This WNK4 antibody is conjugated to FITC
    Application
    Please inquire
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Serine/threonine-protein kinase WNK4 protein (828-1106AA)
    Isotype
    IgG
    Top Product
    Discover our top product WNK4 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))
    Alternative Name
    WNK4 (WNK4 Products)
    Synonyms
    WNK4 antibody, PHA2B antibody, PRKWNK4 antibody, 2010002J11Rik antibody, Pha2b antibody, Prkwnk4 antibody, Ac2-059 antibody, WNK lysine deficient protein kinase 4 antibody, WNK4 antibody, Wnk4 antibody
    Background

    Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).

    Aliases: PHA 2B antibody, PHA2B antibody, PRKWNK 4 antibody, PRKWNK4 antibody, Protein kinase lysine deficient 4 antibody, Protein kinase lysine-deficient 4 antibody, Protein kinase with no lysine 4 antibody, Serine/threonine protein kinase WNK4 antibody, Serine/threonine-protein kinase WNK4 antibody, WNK lysine deficient protein kinase 4 antibody, Wnk4 antibody, WNK4_HUMAN antibody

    UniProt
    Q96J92
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