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VRK2 antibody (AA 317-472) (Biotin)

VRK2 Reactivity: Human ELISA Host: Rabbit Polyclonal Biotin
Catalog No. ABIN7169219
  • Target See all VRK2 Antibodies
    VRK2 (Vaccinia Related Kinase 2 (VRK2))
    Binding Specificity
    • 15
    • 8
    • 7
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    AA 317-472
    Reactivity
    • 33
    • 19
    • 1
    Human
    Host
    • 45
    • 2
    • 1
    Rabbit
    Clonality
    • 47
    • 1
    Polyclonal
    Conjugate
    • 16
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This VRK2 antibody is conjugated to Biotin
    Application
    • 39
    • 24
    • 13
    • 13
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Serine/threonine-protein kinase VRK2 protein (317-472AA)
    Isotype
    IgG
    Top Product
    Discover our top product VRK2 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    VRK2 (Vaccinia Related Kinase 2 (VRK2))
    Alternative Name
    VRK2 (VRK2 Products)
    Synonyms
    2810003O05Rik antibody, AI447698 antibody, vaccinia related kinase 2 antibody, VRK2 antibody, Vrk2 antibody
    Background

    Background: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates \'Thr-18\' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.

    Aliases: 2810003O05Rik antibody, AI447698 antibody, EC 2.7.11.1 antibody, Serine/threonine protein kinase VRK2 antibody, Serine/threonine-protein kinase VRK2 antibody, Vaccinia related kinase 2 antibody, Vaccinia virus B1R related kinase 2 antibody, Vaccinia-related kinase 2 antibody, VRK 2 antibody, VRK2 antibody, VRK2_HUMAN antibody

    UniProt
    Q86Y07
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