PIM3 antibody (AA 278-326)

Catalog No. ABIN7169149

Product Details anti-PIM3 Antibody

Target: PIM3 (Pim-3 Oncogene (PIM3))

Binding Specificity: AA 278-326

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIM3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase pim-3 protein (278-326AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PIM3

Target: PIM3 (Pim-3 Oncogene (PIM3))

Alternative Name: PIM3 (PIM3 Products)

Synonyms: pim1-a antibody, pim-3 antibody, BC026639 antibody, Kid1 antibody, Serine/threonine-protein kinase Pim-3 antibody, Pim-3 proto-oncogene, serine/threonine kinase S homeolog antibody, Pim-3 proto-oncogene, serine/threonine kinase antibody, pim-3 oncogene antibody, proviral integration site 3 antibody, pim3 antibody, pim3.S antibody, PIM3 antibody, Pim3 antibody

Background:

Background: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.

Aliases: Kid 1 antibody, Kid1 antibody, Kinase induced by depolarization antibody, ONCOGENE PIM3 antibody, PIM 3 antibody, Pim 3 oncogene antibody, Pim-3 proto-oncogene, serine/threonine kinase antibody, PIM3 antibody, Pim3 oncogene antibody, PIM3_HUMAN antibody, Protein kinase Kid 1 antibody, Protein kinase Kid1 antibody, Serine/threonine kinase Pim 3 antibody, Serine/threonine kinase Pim3 antibody, Serine/threonine protein kinase Pim 3 antibody, Serine/threonine protein kinase Pim3 antibody, Serine/threonine-protein kinase Pim-3 antibody

UniProt: Q86V86

Pathways: Negative Regulation of Hormone Secretion