SRSF1 antibody (AA 1-248)

Catalog No. ABIN7168966

Product Details anti-SRSF1 Antibody

Target: SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))

Binding Specificity: AA 1-248

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRSF1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Serine/arginine-rich splicing factor 1 protein (1-248AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SRSF1

Target: SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))

Alternative Name: SRSF1 (SRSF1 Products)

Synonyms: ASF antibody, SF2 antibody, SF2p33 antibody, SFRS1 antibody, SRp30a antibody, 1110054N12Rik antibody, 5730507C05Rik antibody, 6330415C05Rik antibody, AI482334 antibody, AW491331 antibody, Asf antibody, Sf2 antibody, Sfrs1 antibody, DKFZp469K2419 antibody, sfrs1 antibody, sfrs1b antibody, wu:fb80g05 antibody, zgc:111894 antibody, zgc:65898 antibody, zgc:76897 antibody, asf antibody, sf2 antibody, sf2p33 antibody, srp30a antibody, sfrs1a antibody, sfrs1l antibody, wu:fb52g10 antibody, wu:fb97g12 antibody, zgc:66146 antibody, serine and arginine rich splicing factor 1 antibody, serine/arginine-rich splicing factor 1 antibody, serine/arginine-rich splicing factor 1b antibody, serine/arginine-rich splicing factor 1 L homeolog antibody, serine/arginine-rich splicing factor 1a antibody, SRSF1 antibody, Srsf1 antibody, srsf1b antibody, srsf1.L antibody, srsf1a antibody

Background:

Background: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5\\\'- and 3\\\'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5\\\'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5\\\'-RGAAGAAC-3\\\' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5\\\'-CGAGGCG-3\\\' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.

Aliases: Alternative splicing factor 1 antibody, Alternative-splicing factor 1 antibody, arginine/serine-rich 1 antibody, ASF 1 antibody, ASF antibody, ASF-1 antibody, ASF1 antibody, FLJ53078 antibody, MGC5228 antibody, P33 subunit antibody, Pre mRNA splicing factor SF2 P33 subunit antibody, pre-mRNA-splicing factor SF2 antibody, Serine/arginine-rich splicing factor 1 antibody, SF2 antibody, SF2P33 antibody, SFRS1 antibody, Splicing factor 2 alternate splicing factor antibody, Splicing factor 2 antibody, Splicing factor antibody, Splicing factor arginine/serine rich 1 antibody, SR Splicing factor 1 antibody, SRp30a antibody, srsf1 antibody, SRSF1_HUMAN antibody

UniProt: Q07955

Pathways: Ribonucleoprotein Complex Subunit Organization