HTRA2 antibody (AA 334-458)

Catalog No. ABIN7368316

Product Details anti-HTRA2 Antibody

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Binding Specificity: AA 334-458

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTRA2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Serine protease HTRA2, mitochondrial protein (334-458AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Alternative Name: HTRA2 (HTRA2 Products)

Synonyms: CG8464 antibody, DmHtrA2 antibody, Dmel\\CG8464 antibody, HtrA2/Omi antibody, Omi antibody, dOmi antibody, domi antibody, htrA2 antibody, omi antibody, HTRA2 antibody, PRSS25 antibody, OMI antibody, PARK13 antibody, AI481710 antibody, Prss25 antibody, mnd2 antibody, HTRA2-related serine protease antibody, HtrA serine peptidase 2 antibody, HtrA2 antibody, HTRA2 antibody, htra2 antibody, Htra2 antibody

Background:

Background: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.

Aliases: High temperature requirement protein A2 antibody, HTRA 2 antibody, HtrA like serine protease antibody, HtrA serine peptidase 2 antibody, HtrA, E. coli, homolog of, 2 antibody, HtrA2 antibody, HTRA2_HUMAN antibody, mitochondrial antibody, Omi stress regulated endoprotease antibody, Omi stress-regulated endoprotease antibody, PARK 13 antibody, PARK13 antibody, Protease serine 25 antibody, PRSS 25 antibody, PRSS25 antibody, Serine protease 25 antibody, Serine protease HTRA2 antibody, Serine protease HTRA2 mitochondrial antibody, Serine protease htra2 mitochondrial precursor antibody, Serine protease omi antibody, Serine proteinase OMI antibody

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity