HTRA1 antibody (AA 23-248)

Catalog No. ABIN7168916

Product Details anti-HTRA1 Antibody

Target: HTRA1 (HtrA Serine Peptidase 1 (HTRA1))

Binding Specificity: AA 23-248

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTRA1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Serine protease HTRA1 protein (23-248AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HTRA1

Target: HTRA1 (HtrA Serine Peptidase 1 (HTRA1))

Alternative Name: HTRA1 (HTRA1 Products)

Synonyms: htra1 antibody, zgc:92029 antibody, zgc:172061 antibody, l56 antibody, htra antibody, Xhtra1 antibody, prss11 antibody, MGC145723 antibody, ARMD7 antibody, CARASIL antibody, HtrA antibody, L56 antibody, ORF480 antibody, PRSS11 antibody, AI429470 antibody, HTRA antibody, Prss11 antibody, RSPP11 antibody, HTRA1 antibody, HtrA serine peptidase 1a antibody, HtrA serine peptidase 1 antibody, HtrA serine peptidase 1b antibody, Serine protease HTRA1 antibody, HtrA serine peptidase 1 S homeolog antibody, htra1a antibody, HTRA1 antibody, htra1b antibody, htra1 antibody, Htra1 antibody, htra1.S antibody

Background:

Background: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

Aliases: ARMD7 antibody, CARASIL antibody, High-temperature requirement A serine peptidase 1 antibody, HtrA antibody, HtrA serine peptidase 1 antibody, HTRA1 antibody, HTRA1_HUMAN antibody, IGFBP5 protease antibody, L56 antibody, ORF480 antibody, Protease serine 11 (IGF binding) antibody, protease serine 11 antibody, PRSS11 antibody, Serine protease 11 antibody, Serine protease HTRA1 antibody, Serine protease HTRA1 precursor antibody

UniProt: Q92743

Pathways: Growth Factor Binding